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. 2019 Jul 22;116(32):16036–16045. doi: 10.1073/pnas.1902902116

Fig. 3.

Fig. 3.

Human-like Cmah−/−Ldlr−/− mice have a hyperglycemic phenotype. Cmah+/+Ldlr−/− and Cmah−/−Ldlr−/− male and female mice were fed either a control diet or a HFD for 11 wk. (A) Fasting glucose level (male, n = 5 to 13), serum insulin levels before and 15 min after an oral glucose gavage in control diet (B) and HFD (C), and (D) homeostasis model assessment for insulin resistance (HOMA-IR) (male, n = 5 each). (E) Fasting glucose level (female, n = 5 to 10), serum insulin levels before and 15 min after an oral glucose gavage in control diet (F) and HFD (G), and (H) HOMA-IR (female, n = 5 each). (I–L) Glucose tolerance tests and (M–P) insulin tolerance tests (relative to basal glucose level) (male and female, n = 10 each). Mean values ± SEM, *P < 0.05 and **P < 0.01.