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The pathology of Creutzfeldt-Jakob disease. Common features of CJD are spongiform degeneration (seen as holes in a; hematoxylin and eosin stain) and the variable accumulation of prion protein (b; PrP immunostain, brown, Nissl counterstain, blue). Both types of lesion vary in type and extent among patients, and amyloid per se is rare in most cases of human prion disease. Bar = 50μm for both panels.
