Table 1.
Summary of human studies included in analysis
| Reference | Disease | Modality investigated |
No. of patients |
Primary set made public |
Total NO. Of features |
Class of features |
Statistical analysis |
Type of study |
|---|---|---|---|---|---|---|---|---|
| Aerts et al (4), 2014 | NSCLC | CT | 52 | Yes | 440 | FO, SM, TA | ICC | Repeatability, reproducibility |
| Balagurunathan et al (28), 2014 | NSCLC | CT | 32 | Yes | 330 | FO, SM, TA | CCC | Reproducibility |
| Cheng et al (29), 2016 | NSCLC | PET | 56 | No | 12 | TA | ICC | Reproducibility |
| Coroller et al (30), 2016 | NSCLC | CT | 32 | Yes | 1603 | FO, SM, TA | ICC | Repeatability |
| Desseroit et al (31), 2017 | NSCLC | PET, CT | 73 | No | 49 | FO, TA | ICC | Repeatability |
| Desseroit et al (32), 2016 | NSCLC | CT | 32 | Yes | 34 | FO, SM, TA | Mean standard deviation | Repeatability |
| Fave et al (33), 2015 | NSCLC | CBCT | 10 | No | 68 | FO, TA | CCC | Reproducibility |
| Fave et al (34), 2015 | NSCLC | CT | 40 | No | 20 | FO, SM, TA | Spearman correlation | Reproducibility |
| Fave et al (35), 2016 | NSCLC | CT | 134 | No | 55 | FO, TA | Spearman correlation | Reproducibility |
| Fried et al (36), 2014 | NSCLC | CT | 91 | No | 30 | FO, TA | CCC | Reproducibility |
| Huynh et al (37), 2017 | NSCLC | CT | 32 | Yes | 644 | FO, SM, TA | ICC | Repeatability |
| Kalpathy-Cramer et al (38), 2016 | NSCLC | CT | 40 | Yes | 830 | FO, SM, TA | CCC | Reproducibility |
| Leijenaar et al (39), 2013 | NSCLC | PET | 34 | No | 108 | FO, SM, TA | ICC | Repeatability |
| Mackin et al (40), 2015 | NSCLC | CT | 20 | No | 10 | FO, TA | Mean standard deviation | Reproducibility |
| Oliver et al (41), 2015 | NSCLC | PET | 23 | No | 56 | FO, SM, TA | Average percentage difference | Reproducibility |
| Parmar et al (42), 2014 | NSCLC | PET | 20 | Yes | 56 | FO, SM, TA | ICC | Reproducibility |
| Van Velden et al (43), 2016 | NSCLC | PET | 11 | No | 105 | FO, SM, TA | ICC | Reproducibility |
| Yan et al (44), 2015 | NSCLC | PET | 17 | No | 64 | FO, TA | Mean standard deviation | Reproducibility |
| Yip et al (45), 2014 | NSCLC | PET | 26 | No | 4 | TA | Relative difference | Reproducibility |
| Zhao et al (46), 2016 | NSCLC | CT | 32 | No | 89 | FO, SM, TA | CCC | Repeatability, reproducibility |
| Grootjans et al (47), 2016 | Lung cancer | PET | 60 | No | 4 | TA | Mean standard deviation | Reproducibility |
| Koo et al (48), 2017 | Lung cancer | CT | 194 | No | 9 | FO, SM | ICC | Reproducibility |
| Lasnon et al (49), 2016 | Lung cancer | PET | 60 | No | 5 | TA | Mean standard deviation | Reproducibility |
| Bagher-Ebadian et al (50), 2017 | Oropharyngeal cancer | CT, CBCT | 18 | No | 165 | FO, TA | Mean absolute percentage change | Reproducibility |
| Bogowicz et al (51), 2016 | Oropharyngeal cancer | CT | 22 | No | 315 | FO, TA | ICC | Reproducibility |
| Lu et al (52), 2016 | Oropharyngeal cancer | PET | 40 | No | 88 | FO, SM, TA | ICC | Reproducibility |
| Doumou et al (53), 2015 | Esophageal cancer | PET | 64 | No | 57 | TA | Spearman correlation | Reproducibility |
| Hatt et al (54), 2013 | Esophageal cancer | PET | 50 | No | 10 | FO, TA | Mean standard deviation | Reproducibility |
| Tixier et al (55), 2012 | Esophageal cancer | PET | 16 | No | 25 | FO, TA | ICC | Reproducibility |
| Hu et al (56), 2016 | Rectal cancer | CT | 40 | No | 775 | TA | ICC | Repeatability |
| Orlhac et al (19), 2014 | Rectal cancer, NSCLC, breast cancer | PET | 28, 24, 54 | No | 41 | FO, TA | Spearman correlation | Reproducibility |
| Van Timmeren et al (57), 2016 | Rectal cancer, lung cancer | CT | 40, 40 | No | 542 | FO, SM, TA | CCC | Repeatability |
| Guan et al (58), 2016 | Cervical cancer | MR | 51 | No | 8 | FO, TA | ICC | Reproducibility |
| Galavis et al (59), 2010 | Various solid tumors | PET | 20 | No | 50 | FO, TA | Average percentage difference | Reproducibility |
| Hatt et al (60), 2015 | Various solid tumors | PET | 555 | No | TA | Spearman correlation | Reproducibility | |
Abbreviations: CBCT = cone beam computed tomography; CCC = concordance correlation coefficient; CT = computed tomography; FO = first order; ICC = intraclass correlation coefficient; MR = magnetic resonance; NSCLC = non-small cell lung cancer; PET = positron emission to-mography; SM = shape metric; TA = textural analysis.