Figure 6.

(A, B) Effect of SIP on oxidative stress in MMP⁺ treated C6 cells. C6 cells were transfected with control-plasmid and SIP-plasmid for 2 hours prior to treatment with 500 μM MPP⁺ for 24 hours, then ROS generation and antioxidant enzymes SOD activity were determined respectively. Data were presented as fold of the control group. Data were displayed as mean ±SD. ** P<0.01 versus control. ^## P<0.01 versus MMP⁺ treatment alone group. SIP – steroid receptor coactivator-interacting protein; MPP⁺ – 1-methyl-4-phenylpyridinium; ROS – reactive oxygen species; SOD – superoxide dismutase; SD – standard deviation.