TABLE 2.
Annotation, predicted functions and distribution among shellfish A. cryaerophilus strains of virulence-associated genes.
| Annotation | Function | Virulence trait | Strainsa |
| flaA | Flagellin A | Motility and/or adhesion | M830MA |
| Flagellar assembly protein H | Flagellar assembly protein H | Motility and/or adhesion | G13RTA, M830MA |
| Flagellar basal body rod modification protein | Flagellar basal body rod modification protein | Motility and/or adhesion | G13RTA, M830MA |
| Flagellar basal body rod protein FlgG | Flagellar basal body rod protein FlgG | Motility and/or adhesion | G13RTA, M830MA |
| Flagellar basal body-associated protein FliL | Flagellar basal body-associated protein FliL | Motility and/or adhesion | M830MA |
| Flagellar biosynthesis protein FliR | Flagellar biosynthesis protein FliR | Motility and/or adhesion | G13RTA, M830MA |
| Flagellar filament 33 kDa core protein | Flagellar filament 33 kDa core protein | Motility and/or adhesion | G13RTA, G18RTA |
| Flagellar hook-associated protein FlgL | Flagellar hook-associated protein FlgL | Motility and/or adhesion | G13RTA, M830MA |
| Flagellar hook-length control protein FliK | Flagellar hook-length control protein FliK | Motility and/or adhesion | G13RTA, M830MA |
| Flagellar motor switch protein | Flagellar motor switch protein | Motility and/or adhesion | G13RTA, M830MA |
| Flagellin N-methylase | Flagellin N-methylase | Motility and/or adhesion | G13RTA, M830MA |
| flgB | Flagellar basal body rod protein FlgB | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flgC | Flagellar basal-body rod protein FlgC | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flgE1 | Flagellar hook protein FlgE | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flgG | Flagellar basal-body rod protein FlgG | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flgH | Flagellar L-ring protein | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flgI | Flagellar P-ring protein | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flgK | Flagellar hook-associated protein 1 | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flhA | Flagellar biosynthesis protein FlhA | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flhB1 | Flagellar biosynthetic protein FlhB | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| flhF | Flagellar biosynthesis protein FlhF | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliD | Flagellar hook-associated protein 2 | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliE | Flagellar hook-basal body complex protein FliE | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliF | Flagellar M-ring protein | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliG | Flagellar motor switch protein FliG | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliI | Flagellum-specific ATP synthase | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliM | Flagellar motor switch protein FliM | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliN1 | Flagellar motor switch protein FliN | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliP | Flagellar biosynthetic protein FliP | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliQ | Flagellar biosynthetic protein FliQ | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliS | Flagellar protein FliS | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| fliW2 | Flagellar assembly factor FliW2 | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| hag | Flagellin | Motility and/or adhesion | G13RTA, G18RTA |
| motB | Motility protein B | Motility and/or adhesion | G18RTA |
| ylxH | Flagellum site-determining protein YlxH | Motility and/or adhesion | G13RTA, G18RTA, M830MA |
| acrB | Multidrug efflux pump subunit AcrB | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| adh2 | Long-chain-alcohol dehydrogenase 2 | Antimicrobial resistance | G18RTA |
| arnA | Bifunctional polymyxin resistance protein ArnA | Antimicrobial resistance | G13RTA |
| arsB | Arsenical pump membrane protein | Antimicrobial resistance | G18RTA |
| arsC1 | Glutaredoxin arsenate reductase | Antimicrobial resistance | G18RTA |
| arsC2 | Arsenate reductase | Antimicrobial resistance | G18RTA |
| bcr | Bicyclomycin resistance protein | Antimicrobial resistance | G13RTA, M830MA |
| bepC | Outer membrane efflux protein BepC | Antimicrobial resistance | G18RTA |
| bepD | Efflux pump periplasmic linker BepD | Antimicrobial resistance | G18RTA |
| bepE | Efflux pump membrane transporter BepE | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| bepF | Efflux pump periplasmic linker BepF | Antimicrobial resistance | G13RTA, M830MA |
| Enterobactin exporter EntS | Enterobactin exporter EntS | Antimicrobial resistance | G13RTA |
| hcpA | Beta-lactamase HcpA | Antimicrobial resistance | M830MA |
| hcpC | Putative beta-lactamase HcpC | Antimicrobial resistance | G13RTA, M830MA |
| lmrA | Multidrug resistance ABC transporter ATP-binding and permease protein | Antimicrobial resistance | G13RTA |
| marA | Multiple antibiotic resistance protein MarA | Antimicrobial resistance | M830MA |
| mdtB | Multidrug resistance protein MdtB | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| mexA | Multidrug resistance protein MexA | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| mexB | Multidrug resistance protein MexB | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| mrdA | Penicillin-binding protein 2 | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| pbpF | Penicillin-binding protein 1F | Antimicrobial resistance | G13RTA, G18RTA |
| Putative multidrug export ATP-binding/permease protein | Putative multidrug export ATP-binding/permease protein | Antimicrobial resistance | G13RTA, G18RTA |
| srpC | Putative chromate transport protein | Antimicrobial resistance | G18RTA |
| ttgA | Putative efflux pump periplasmic linker TtgA | Antimicrobial resistance | G13RTA, G18RTA, M830MA |
| ttgC | Putative efflux pump outer membrane protein TtgC | Antimicrobial resistance | G13RTA, M830MA |
| ttgI | Toluene efflux pump outer membrane protein TtgI | Antimicrobial resistance | G18RTA |
| ykkD | Multidrug resistance protein YkkD | Antimicrobial resistance | G18RTA |
| btuB | Vitamin B12 transporter BtuB | Fe acquisition | G18RTA |
| fbpC | Fe(3+) ions import ATP-binding protein FbpC | Fe acquisition | G13RTA |
| Ferredoxin–NADP reductase | Ferredoxin–NADP reductase | Fe acquisition | G13RTA |
| futA1 | Iron uptake protein A1 | Fe acquisition | G13RTA |
| Gram-negative bacterial TonB protein | Gram-negative bacterial TonB protein | Fe acquisition | M830MA |
| hemE | Uroporphyrinogen decarboxylase | Fe acquisition | G18RTA |
| hemH1 | Ferrochelatase | Fe acquisition | G18RTA |
| hmuT | Hemin-binding periplasmic protein HmuT | Fe acquisition | G13RTA, G18RTA, M830MA |
| hmuU | Hemin transport system permease protein HmuU | Fe acquisition | G13RTA, G18RTA, M830MA |
| hmuV | Hemin import ATP-binding protein HmuV | Fe acquisition | G13RTA, G18RTA |
| hssS | Heme sensor protein HssS | Fe acquisition | G13RTA, G18RTA, M830MA |
| hxuA | Heme/hemopexin-binding protein | Fe acquisition | G13RTA, M830MA |
| hxuB | Heme/hemopexin transporter protein | Fe acquisition | G13RTA, M830MA |
| isdE | High-affinity heme uptake system protein IsdE | Fe acquisition | G18RTA |
| tdhA | TonB-dependent heme receptor A | Fe acquisition | G13RTA |
| esiB1 | Secretory immunoglobulin A-binding protein EsiB | Immunoavoidance | G18RTA |
| Plasmid stabilization system protein | Plasmid stabilization system protein | Plasmid stabilization | G13RTA |
| virF | Virulence regulon transcriptional activator VirF | Virulence regulator | G18RTA |
| epsF | Type II secretion system protein F | Toxin secretion | G13RTA |
| hxcR | Putative type II secretion system protein HxcR | Toxin secretion | G13RTA |
| prsE | Type I secretion system membrane fusion protein PrsE | Toxin secretion | G18RTA |
| Putative two-component membrane permease complex subunit SMU 747c | Putative two-component membrane permease complex subunit SMU_747c | Toxin secretion | G18RTA |
| bvgS1 | Virulence sensor protein BvgS | Virulence gene regulation | M830MA |
| bvgS2 | Virulence sensor protein BvgS | Virulence gene regulation | M830MA |
| bvgS3 | Virulence sensor protein BvgS | Virulence gene regulation | M830MA |
aResults for strain M830A not shown since genome analysis and isolation history indicated this to represent a clone of M830MA.