Skip to main content
. Author manuscript; available in PMC: 2019 Aug 12.
Published in final edited form as: Future Virol. 2019 Jan 21;14(2):107–122. doi: 10.2217/fvl-2018-0161

Figure 2. The process of ubiquitination.

Figure 2.

Ubiquitin is first activated by a ubiquitin-activating enzyme (E1) in an ATP-dependent reaction. The activated ubiquitin is then transferred to a ubiquitin-conjugating enzyme (E2). Subsequently, the E2-E3 enzyme complex conjugates one or more ubiquitin proteins to the substrate.