Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Prog Retin Eye Res. 2018 Nov 16;71:88–113. doi: 10.1016/j.preteyeres.2018.11.005

Table 2.

Known agonists of the voltage-gated channel receptors present within the human cornea. Chemical structure, major source of isolation, and target receptor are listed.

Chemical Structure Source Target
Capsaicin graphic file with name nihms-1536695-t0001.jpg Capsicum sp. (chili peppers) TRPV1
Resiniferatoxin graphic file with name nihms-1536695-t0002.jpg Euphorbia resinifera (cactus) TRPV1
Anandamide graphic file with name nihms-1536695-t0003.jpg endogenous fatty acid metabolism TRPV1
Arachidonic acid graphic file with name nihms-1536695-t0004.jpg endogenous fatty acid metabolism TRPV1
Gingerol graphic file with name nihms-1536695-t0005.jpg Z. officinale (ginger) TRPV1
Menthol graphic file with name nihms-1536695-t0006.jpg L. menthe, L. salvia TRPM8
Eucalyptol graphic file with name nihms-1536695-t0007.jpg E. globulus TRPM8
Icilin graphic file with name nihms-1536695-t0008.jpg Synthetic TRPM8, TRPA1
Allyl Isothiocyanate graphic file with name nihms-1536695-t0009.jpg B. nigra, B. juncea, B. hirta TRPA1
Cinnamaldehyde graphic file with name nihms-1536695-t0010.jpg C. cassia TRPA1
Allicin graphic file with name nihms-1536695-t0011.jpg Alliaceae (garlic) TRPA1, TRPV1
2-chloro-acetophen graphic file with name nihms-1536695-t0012.jpg Synthetic (CN tear gas) TRPA1