Table 2.

Optimal IGA × BSA cutoffs for predictability of PASI 90 and DLQI 0/1 MDA definition (pooled secukinumab 300 mg treatment group)

Week	IGA × BSA	Sensitivity	Specificity	Youden indexa
4	8.90	0.8440	0.9000	0.74398
8	3.20	0.8034	0.8261	0.62949
12	2.10	0.7790	0.8191	0.59815
24	1.02	0.7317	0.8190	0.55073
36	0.62	0.8030	0.8333	0.63636
52	1.00	0.7857	0.8605	0.64626

BSA, body surface area; DLQI, Dermatology Life Quality Index; IGA, 5-point Investigator's Global Assessment; MDA, minimal disease activity; PASI, Psoriasis Area and Severity Index.

^aYouden index = sensitivity + specificity − 1.