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. 2019 Apr 4;116(1):42–51. doi: 10.1159/000497781

Table 1.

Collected variables and definitions

Perinatal variables Postnatal variables
Delivery mode (i.e., vaginal or caesarian section) Gestational age

Single or multiple births Birthweight

Preterm premature rupture of membranes (i.e., ≥24 h before delivery) Apgarscore

Meconium-stained amniotic fluid Patent ductus arteriosus

Medication

Antibiotics
1 Total duration of treatment (days)
2 Duration of antibiotic treatment initiated within 24 h postnatally (0, 1–3, or >3 days)
3 Antibiotic exposure (yes/no)

Ventilation mode

Diagnosis of necrotizing enterocolitis

Diagnosis of spontaneous intestinal perforation

Diagnosis of sepsis, including the causative pathogen:
1 Gram-positive bacteria (including CoNS)
2 Gram-negative bacteria
3 Fungi
4 CoNS

Number of red blood cell transfusions

Central (umbilical line and/or peripherally inserted central catheter) and peripheral venous catheter use:
1 Cumulative number of days a certain line was present
2 Presence of a line within 48 h prior to LOS onset

Parenteral feeding practices (lipids or amino acids)

Enteral feeding practices
1 Breast-fed, defined as the daily average enteral feeding volume consisting of >80% breastmilk, including donor milk
2 Formula-fed, defined as the daily average enteral feeding volume consisting of >50% formula
3 Combination of breastmilk and formula, that encompasses infants not meeting the criteria for (1) and (2)

Time to full enteral feeding, defined as at least 2 consecutive days without additional parenteral feeding administration

Radiologic results (i.e., abdominal radiography)

Laboratory results (i.e., C-reactive protein and blood cultures)