Table 1.
Collected variables and definitions
| Perinatal variables | Postnatal variables |
|---|---|
| Delivery mode (i.e., vaginal or caesarian section) | Gestational age |
| Single or multiple births | Birthweight |
| Preterm premature rupture of membranes (i.e., ≥24 h before delivery) | Apgarscore |
| Meconium-stained amniotic fluid | Patent ductus arteriosus |
| Medication | |
| Antibiotics 1 Total duration of treatment (days) 2 Duration of antibiotic treatment initiated within 24 h postnatally (0, 1–3, or >3 days) 3 Antibiotic exposure (yes/no) |
|
| Ventilation mode | |
| Diagnosis of necrotizing enterocolitis | |
| Diagnosis of spontaneous intestinal perforation | |
| Diagnosis of sepsis, including the causative pathogen: 1 Gram-positive bacteria (including CoNS) 2 Gram-negative bacteria 3 Fungi 4 CoNS |
|
| Number of red blood cell transfusions | |
| Central (umbilical line and/or peripherally inserted central catheter) and peripheral venous catheter use: 1 Cumulative number of days a certain line was present 2 Presence of a line within 48 h prior to LOS onset |
|
| Parenteral feeding practices (lipids or amino acids) | |
| Enteral feeding practices 1 Breast-fed, defined as the daily average enteral feeding volume consisting of >80% breastmilk, including donor milk 2 Formula-fed, defined as the daily average enteral feeding volume consisting of >50% formula 3 Combination of breastmilk and formula, that encompasses infants not meeting the criteria for (1) and (2) |
|
| Time to full enteral feeding, defined as at least 2 consecutive days without additional parenteral feeding administration | |
| Radiologic results (i.e., abdominal radiography) | |
| Laboratory results (i.e., C-reactive protein and blood cultures) | |