Table 2.
Clinical and biochemical characteristics at the onset of Graves disease in 110 children
| Clinical and biochemical parameters | Proportion of patients with a positive finding, % |
|---|---|
| Tachycardia (n = 97)* | 37 |
| Goiter (n = 110) | 73 |
| Tremor(n = 99) | 43 |
| Exophthalmus (n = 108) | 32 |
| Co-morbidity with other autoimmune diseases(n = 108) | 26 |
| Positive family history of thyrotoxicosis (n = 102) | 19 |
| Raised levels of TRAb (n = 105) | 93 |
| Raised levels of TPO ab (n = 90) | 77 |
| Levels of FT4: | |
| ≥25 pmol/L (n = 109) | 92 |
| ≥50 pmol/L (n = 109) | 61 |
*
Tachycardia defined as heart rate >140/min in children aged 2–5 years, >120/min in children aged 5–12 years and >100/min in children aged >12 years.
TRAb, TSH receptor stimulating antibody; TPO ab, anti-thyroid peroxidase antibody; FT4, free thyroxine.