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The classical model of allostery is based on structural descriptions of two end states that are defined by two discrete basins in the free energy landscape of the protein. Transition between the two states defines conformation-based allostery into paths: the “induced-fit”/KNF model and the “conformation-selection”/MWC model. As decided by the allosteric effector, one path may be taken over the other, but at any given time, significant flux is expected to be present in both pathways.
