Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Computational umbrella-sampling-based assessment of conformation-based allostery in the Src kinase domain. The free energy landscape shows the presence of “inactive” and “active” conformation basins and also two intermediates. Assembly of the R-spine by activation loop phosphorylation or the L297F/V281F double mutant shifts the Src populations into the “active” basin of the free energy landscape. Data are adapted from references 21–23.
