Table 5.

Advantages and disadvantages of IVIG versus PLEX in MG

Pro-PLEX	Con-PLEX	Pro-IVIG	Con-IVIG
Probably effective	No RCT	Positive RCT	Insurance coverage limitations; not FDA approved for MG
Longer track record	Morbidity; need for central access	Ease of use	Shorter track record
May work faster	Sophisticated equipment; need for trained staff	Generally well-tolerated	Rare side effects: anaphylaxis, kidney injury, thrombosis

Abbreviations: FDA, US Food and Drug Administration; IVIG, intravenous immunoglobulin; MG, myasthenia gravis; PLEX, plasma exchange; RCT, randomized, controlled trial.