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. 2019 Aug 12;14(8):e0220837. doi: 10.1371/journal.pone.0220837

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© 2019 Leader et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Global longitudinal strain (GLS) tracking analysis (a), showing the region of interest and the strain assessment at both one month and three months in normotensive (N), hypertensive (H) and hypertensive with spironolactone (H+SP) groups. (b) Analysis of the endocardium layer and (c) myocardium layer from normotensive (N), hypertensive (H) and hypertensive animals with spironolactone (H+SP) following one, two and three months. Values are shown as mean ± standard deviation. Significant differences between N and H is indicated by *, p<0.05 *, p<0.01 **, p<0.001 *** Significant differences between N and H+SP is indicated by †, p<0.05 ^†, p<0.01 ^†† Significant differences between H and H+SP is indicated by #, p< 0.05 ^#, p<0.01 ^##.