Table 2. Functional Connectivity with significant difference between CNP and HC on the whole brain analysis.
| ROI (MNI Coordinates) | ROI | MNI coordinates | T-values | p-FDR |
|---|---|---|---|---|
| CNP>HC | ||||
| rt. DLPFC (36, 40, 18) | rt. Central Opercular Cortex | 55, -7, 5 | 3.50 | 0.012 |
| rt. Parietal Operculum Cortex | 45, -28, 24 | 3.57 | 0.024 | |
| rt. aIC | 38, 14, 10 | 3.70 | 0.028 | |
| rt. Supramarginal Gyrus | 58, -28, 34 | 3.96 | 0.028 | |
| lt. aIC | -32, 16, 6 | 4.26 | 0.028 | |
| lt. hippocampus (26, -10, -27) | lt. Frontal Pole | -13, 60, 10 | 4.03 | 0.046 |
| lt. Superior Frontal Gyrus | -11, 18, 60 | 4.33 | 0.046 | |
| rt. Frontal Pole (39, 51, 13) | lt. Postcentral Gyrus | -58, -10, 30 | 4.27 | 0.034 |
| rt. Precingulate Gyrus | 53, -7, 30 | 4.46 | 0.034 | |
| rt. aIC (38, 14, 10) | rt. Frontal Pole | 25, 53, -15 | 4.46 | 0.038 |
| rt. Cuneal Cortex (3, -88, 37) | rt. Superior Parietal Lobule | 27, -42, 70 | 4.45 | 0.040 |
| CNP<HC | ||||
| rt. DLPFC (36, 40, 18) | dorsal PCC | 2, -36, 36 | 4.61 | 0.012 |
| rt. Middle Temporal Gyrus | 60, -19, -22 | 4.35 | 0.024 | |
| rt. Pcu | 3, -59, 33 | 3.94 | 0.028 | |
| ventral PCC | -1, -46, 30 | 3.94 | 0.028 | |
| ventral PCC | 0, -47, 12 | 3.86 | 0.028 | |
| lt. Angular Gyrus | -51, -59, 27 | 3.60 | 0.047 | |
| lt. DLPFC | -14, 59, 20 | 3.49 | 0.048 | |
| lt. Superior Frontal Gyrus | -25, 20, 56 | 3.46 | 0.048 | |
| Pcu | -1, -57, 24 | 3.45 | 0.048 | |
| rt. Middle Frontal Gyrus | 26, 27, 49 | 4.06 | 0.028 | |
| lt. hippocampus (26, -10, -27) | Post Postcentral Gyrus | 1, -38, 77 | 4.05 | 0.046 |
| dorsal PCC (2, -36, 36) | lt. Pcu | -8, -53, 60 | 4.23 | 0.026 |
| dorsal PCC (-1, -35, 44) | dorsal PCC | 2, -36, 36 | 4.96 | 0.009 |
| rt. Lateral Occipital Cortex | 48, -59, 41 | 4.22 | 0.039 | |
| Middle Cingulate Cortex (12, -29, 44) | lt. Occipital Pole | -6, -95, 19 | 4.92 | 0.009 |
| brain stem | 4, -35, -15 | 4.28 | 0.033 | |
| lt. Middle Temporal Gyrus (-53, -32, -6) | rt. Precingulate Gyrus | 52, 7, 20 | 5.59 | 0.001 |
| lt. Paracingulate Gyrus (-1, 54, 9) | rt. Superior Parietal Lobule | 23, -53, 57 | 4.50 | 0.034 |
MNI coordinates (x, y, z) are shown in mm.
ROI: Region of interest, CNP: chronic neck pain, HC: healthy control, p-FDR: false discovery rate-corrected p-values, rt: right, lt: left, DLPFC: dorsolateral prefrontal cortex, aIC: anterior insular cortex, PCC: posterior cingulate cortex, Pcu: Precuneus Cortex.