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(A) IL-1β in the synovial fluid was significantly higher in the model group than that in the control group (** p <0.01). Higher IL-1β was observed and correlated with AQP1 or AQP3 in the joint synovial fluid (B and C). The content of AQP3 (or AQP1, but not shown) was negatively correlated with cartilage matrix of proteoglycan (D) and collagen II (E) as indicated by the cartilage pathological Mankin’s score (F).
