Table 2.
Hazard ratios (HR) with 95% confidence interval (95% CI) of cancer case fatality according to predefined categories of prediagnostic (I) and diagnostic (II) 25-OHD levels, from crude and adjusted analyses
| na | Crude model | Adjusted modelb | |
|---|---|---|---|
| HR (95% CI) | HR (95% CI) | ||
| I. Prediagnostic 25-OHDc | |||
| 1 [<46 nmol/L] | 114/73 | 1.00 reference | 1.00 reference |
| 2 [46–61 nmol/L] | 154/76 | 0.62 (0.45–0.85) | 0.52 (0.37–0.72) |
| 3 [62–81 nmol/L] | 168/102 | 0.75 (0.56–1.02) | 0.61 (0.44–0.84) |
| 4 [≥82 nmol/L] | 120/62 | 0.64 (0.46–0.91) | 0.46 (0.32–0.66) |
| p for trend | 0.066 | 0.001 | |
| II. Diagnostic 25-OHDc | |||
| 1 [<46 nmol/L] | 138/97 | 1.00 reference | 1.00 reference |
| 2 [46–61 nmol/L] | 136/83 | 0.61 (0.46–0.82) | 0.74 (0.55–0.99) |
| 3 [62–81 nmol/L] | 134/64 | 0.41 (0.30–0.56) | 0.44 (0.32–0.61) |
| 4 [≥82 nmol/L] | 148/69 | 0.36 (0.27–0.50) | 0.41 (0.30–0.57) |
| p for trend | <0.001 | <0.001 |
Notes: aNumber of cases/cancer deaths; bAdjusted for sex, age at diagnosis, season of serum sampling, and serum storage time; cThe two serum samples were collected in average 14.4 years apart.