Table 4.
Hazard ratios (HR) with 95% confidence intervals (95% CI) of cancer case fatality by all possible combinations of season-standardized 25-OHD categories in prediagnostic and diagnostic samples
| 25-OHD level | nb | HR (95% CI)c | |
|---|---|---|---|
| Prediagnostic samplea | Diagnostic samplea | ||
| Low (<46 nmol/L) | Low (<46 nmol/L) | 50/32 | 1.00 reference |
| Low (<46 nmol/L) | Intermediate (46–61 nmol/L) | 23/15 | 0.84 (0.46–1.56) |
| Low (<46 nmol/L) | High (≥62 nmol/L) | 23/11 | 0.53 (0.27–1.05) |
| Intermediate (46–61 nmol/L) | Low (<46 nmol/L) | 47/30 | 0.86 (0.52–1.42) |
| Intermediate (46–61 nmol/L) | Intermediate (46–61 nmol/L) | 51/34 | 0.87 (0.54–1.41) |
| Intermediate (46–61 nmol/L) | High (≥62 nmol/L) | 59/26 | 0.43 (0.26–0.73) |
| High (≥62 nmol/L) | Low (<46 nmol/L) | 37/30 | 1.01 (0.61–1.69) |
| High (≥62 nmol/L) | Intermediate (46–61 nmol/L) | 55/36 | 0.70 (0.43–1.14) |
| High (≥62 nmol/L) | High (≥62 nmol/L) | 211/99 | 0.41 (0.27–0.61) |
| p for trend | <0.001 | ||
Notes: aThe two serum samples were collected in average 14.4 years apart; bNumber of cases/cancer deaths; cAdjusted for sex, age at diagnosis, and serum storage time.