Table 5.
Hazard ratios (HR) with 95% confidence interval (95% CI) of cancer case fatality by tertiles (T) of change in season-standardized 25-OHD between prediagnostic and diagnostic samples, overall (I), and according to time-span between collection of the samples; <10 years (II) and ≥10 years (III)
| 25-OHD changea | nb | HR (95% CI)c |
|---|---|---|
| I. Overall | ||
| T1 (loss) | 186/126 | 1.00 (reference) |
| T2 (stable) | 185/100 | 0.76 (0.58–0.99) |
| T3 (rise) | 185/87 | 0.57 (0.43–0.75) |
| p for trend | <0.001 | |
| II. <10 years | ||
| T1 (loss) | 17/32 | 1.00 (reference) |
| T2 (stable) | 17/36 | 0.94 (0.47–1.87) |
| T3 (rise) | 22/50 | 0.89 (0.46–1.70) |
| Trend | 0.718 | |
| III. ≥10 years | ||
| T1 (loss) | 110/154 | 1.00 (reference) |
| T2 (stable) | 82/149 | 0.70 (0.52–0.93) |
| T3 (rise) | 65/135 | 0.50 (0.37–0.69) |
| p for trend | <0.001 |
Notes: aTertile 1 (loss) −86.8 to −26.4; Tertile 2 (stable) −10.4 to +0.14; Tertile 3 (rise) +9.6 to +27.3; bNumber of cases/cancer deaths; cAdjusted for sex and age at diagnosis.