Table 4.
Association of miRNA-499 rs3746444 A>G polymorphism with AEG
| Genotype | Overall patients (n=1063) vs controls (n=1677) | Stage I/II patients (n=305) vs controls (n=1677) | Stage III/IV patients (n=758) vs controls (n=1677) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Crude OR(95%CI) | P | Adjusted ORa (95%CI) | P | Crude OR(95%CI) | P | Adjusted ORa (95%CI) | P | Crude OR(95%CI) | P | Adjusted ORa (95%CI) | P | |
| GA vs AA | 1.30 (1.09–1.54) | 0.003 | 1.29 (1.08–1.53) | 0.005 | 1.31 (1.00–1.72) | 0.052 | 1.29 (0.98–1.70) | 0.068 | 1.29 (1.06–1.57) | 0.010 | 1.28 (1.05–1.55) | 0.013 |
| GG vs AA | 1.45 (0.91–2.30) | 0.118 | 1.46 (0.92–2.33) | 0.112 | 1.34 (0.64–2.80) | 0.437 | 1.41 (0.67–2.96) | 0.362 | 1.49 (0.90–2.48) | 0.123 | 1.50 (0.90–2.50) | 0.118 |
| GA/GG vs AA | 1.31 (1.11–1.55) | 0.002 | 1.30 (1.10–1.54) | 0.002 | 1.31 (1.01–1.71) | 0.043 | 1.30 (1.00–1.70) | 0.052 | 1.31 (1.09–1.58) | 0.005 | 1.30 (1.08–1.57) | 0.006 |
| GG vs GA/AA | 1.35 (0.85–2.14) | 0.207 | 1.36 (0.86–2.16) | 0.194 | 1.24 (0.60–2.58) | 0.564 | 1.31 (0.63–2.75) | 0.467 | 1.39 (0.84–2.30) | 0.202 | 1.40 (0.84–2.33) | 0.192 |
Notes: aAdjusted for age, sex, smoking status, and alcohol use in a logistic regression model. Bold values are statistically significant (P<0.05).