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. Author manuscript; available in PMC: 2019 Aug 12.
Published in final edited form as: Cell Rep. 2019 Jul 9;28(2):472–485.e5. doi: 10.1016/j.celrep.2019.06.029

Figure 7. Abnormal Splenic B Cell Differentiation and B Cell Response in Mice Lacking MTA2 or Both MTA2 and OCA-B.

Figure 7.

(A) Staining of total splenic B (B220+), marginal zone B (MZB) (B220+CD21hiCD23lo), and follicular B (FOB) (B220+CD21−CD23hi) cells in Vav-Cre Mta2fl/fl and control mice. Frequencies of different cell populations in parental cells are indicated.

(B) Staining of germinal center B (GCB) (B220+CD95+CD38−CD4−) cells in Vav-Cre Mta2fl/fl and control mice immunized by sheep red blood cells (SRBCs).

(C) Numbers of GCB cells and frequencies of GCB cells in splenic B cells are plotted (n = 8 for each genotype; t test; *p = 0.02).

(D) Staining of splenic B, MZB, and FOB cells in mice with indicated genotypes.

(E) Cell numbers of different B cell subsets are plotted (n = 10 for control, n = 9 for Vav-Cre Mta2fl/fl, n = 5 for Oca-B−/− and DKO mice; t test; *p < 0.05, **p < 0.01, ***p < 0.001).