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Classification of NENs
| Differentiation features | Grade | Ki 67 | Functioning status |
|---|---|---|---|
| Well-differentiated (NE tumors) |
1 | <3% | Functioning |
| 2 | 3–20% | ||
| 3 | >20% | ||
| Poor-differentiated (NE carcinomas) |
3 | >20% | Non- functioning |
Abbreviations: NE, neuroendocrine; NENs, neuroendocrine neoplasms.
