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. 2019 Aug 6;10(47):4840–4856. doi: 10.18632/oncotarget.27106

Figure 7. P2X7R expression increases in vivo tumor growth.

Figure 7

Male athymic mice were subcutaneously inoculated with (A) 1.4 × 106 or (B) 3.0x106 U138-wt, U138-P2X7 polyclone or U138-P2X7 clone cells. Tumor volume was either measured in excised tumors on p.i. day 15, or in vivo measured by caliper. Values are mean ± S.E.M. Data were analyzed by ANOVA followed by Tukey test *Significantly different from U138-wt and # significantly different from the U138-P2X7 polyclone (p < 0.05) (n = 3–6 animals per group). GL261 cells were subcutaneously inoculated in mice and the 30 μM A740003 was intramass-administered. (C) Size of in vivo tumors. Values are shown as mean ± S.E.M. Data were analyzed by ANOVA followed by Tukey test. *Significantly different from DMSO (n = 4–5 animals per group). (D) The tumor volume of excised tumors at day 15 post-inoculum (4 animals per group). The values are presented as mean ± S.E.M. Data were analyzed by Student’s t- test.