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Structure of a substrate analog of the forward reaction. A, kinetic activity of hAPRT for ADE (black), Hx (blue), and ADE in the presence of 75 μm Hx (red). B, superimposition of the Hx-PRPP-Mg2+- (orange) onto the PRPP- (yellow) hAPRT structure (RMSD = 0.62 Å). C and D, Fo – Fc omit electron density map for Hx (C) and PRPP (D) contoured at 3σ from the Hx-PRPP-Mg2+-hAPRT structure. The hydrogen bond distances are indicated in Angstroms.
