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Cortisol-metabolizing reactions by B. adolescentis, C. scindens, B. desmolans, P. lymphophilum, and E. lenta. Boxed reaction shows 20β-HSDH oxidizes the coenzyme NADH to transform cortisol into 20β-dihydrocortisol. Cortisol + NADH ⇌ 20β-dihydrocortisol + NAD+. This reaction reduces the double-bonded oxygen at C-20 (highlighted in red) on cortisol and is fully reversible.
