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The YYIYVI sequence competitively inhibits HSC70 binding to CTA1. HSC70 was perfused over a CTA1-coated SPR sensor in the absence of peptide, in the presence of mutant GQTILSGHSTYYLYVL peptide, or in the presence of the WT GQTILSGHSTYYIYVI peptide. Ligands were removed from the perfusion buffer after 200 s. Following an additional 100 s of dissociation, final RIU values were recorded.
