Schematic diagram showing the intersection between sulfide oxidation and energy metabolism.
a, in proliferating cells, oxidation of nutrients for biomass synthesis leads to electron capture by NAD+ and other cofactors, which are recycled by the ETC. An H2S-induced ETC backup leads to a shortage of uridine and aspartate. DHO and DHOD, dihydroorotate and dihydroorotate dehydrogenase, respectively. b, reactions catalyzed by the sulfide oxidation pathway enzymes.