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. 2019 Jun 18;294(32):12077–12090. doi: 10.1074/jbc.RA119.009442

Figure 1.

Figure 1.

Schematic diagram showing the intersection between sulfide oxidation and energy metabolism. a, in proliferating cells, oxidation of nutrients for biomass synthesis leads to electron capture by NAD+ and other cofactors, which are recycled by the ETC. An H2S-induced ETC backup leads to a shortage of uridine and aspartate. DHO and DHOD, dihydroorotate and dihydroorotate dehydrogenase, respectively. b, reactions catalyzed by the sulfide oxidation pathway enzymes.