Figure 1.

Transient expression of PMP22_WT augments Gd³⁺-sensitive, DVF-induced whole-cell currents in tsA201 cells. Average whole-cell currents were recorded from control (A) or PMP22–WT–expressing (B) cells exposed to +divalent solution (left, +Ca²⁺/Mg²⁺), divalent-free solution (center, −Ca²⁺/Mg²⁺), or divalent-free plus 10 μm Gd³⁺ solution (right). C, average current-voltage relationships (IVs) measured in +divalents (left) or −divalents (right) solutions. D, average Gd³⁺-sensitive current-voltage relationships for DVF-induced currents measured for control (○, n = 16) or PMP22_WT expressing (●, n = 14) cells. *, p < 0.05; **, p ≤0.02; ***, p < 0.01.