Figure 3.

Divalent-free induced current in Schwann cells is permeable to both Cs⁺ and Na⁺ and similar to TrpC channels. A, average whole-cell currents recorded from WT rat Schwann cells exposed to +divalents (left, +Ca²⁺/Mg²⁺), divalent-free (center, −Ca²⁺/Mg²⁺), or divalent-free plus 10 μm Gd³⁺ (right) solutions. B, average IVs for Gd³⁺-sensitive for divalent-free (●) and for currents recorded in +Ca²⁺/Mg²⁺ solution (○). n = 7. *, p < 0.05; **, p < 0.01. C, average IVs recorded from rat Schwann cells exposed to +divalents (left, +Ca²⁺/Mg²⁺) or divalent-free (right, −Ca²⁺/Mg²⁺) solution with Na⁺ (●, n = 6) or Cs⁺ (□, n = 7) as the main external cation.