Figure 4.

TrJ-Het mouse Schwann cells exhibit Gd³⁺-sensitive, DVF-induced whole-cell currents larger than littermate WT cells. Representative whole-cell currents were recorded from WT (A) or TrJ-Het (B) mouse Schwann cells exposed to +divalent (left, +Ca²⁺/Mg²⁺), divalent-free (center, −Ca²⁺/Mg²⁺), or divalent-free plus 10 μm Gd³⁺ (right) solutions. C, average IVs for Gd³⁺-sensitive DVF-induced currents measured from WT (♢, n = 21) or TrJ-Het (♦, n = 6) cells. D, concentration-response curves for Gd³⁺ block of DVF-induced currents recorded from WT (♢) or TrJ-Het (♦) Schwann cells. Solid lines represent data fit with Hill equation. n ≤4 for all concentrations. *, p < 0.05; **, p ≤0.02.