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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Diabetes Complications. 2019 May 29;33(9):668–674. doi: 10.1016/j.jdiacomp.2019.05.016

Figure 2. IL-17A elicits capillary cell death and degeneration in the retina.

Figure 2.

A) Representative images of acellular capillaries and degeneration in retinal capillary beds of C57BL/6 and IL17A−/− non-diabetic and diabetic mice (scale bars of all images = 75 μm). Circled area highlights an acellular capillary. B) Quantification of acellular capillaries within a 1.10 mm2 area of each retina of non-diabetic (ND) and diabetic (DB) C57BL/6 (square black data point) and IL17A−/−(grey circle data point) mice. Each data point represents an individual retina from 8 different mice. p-value was first equated by two-way ANOVA analysis and then an unpaired t-test with Tukey’s post-hoc analysis. C) Mean quantifications of acellular capillary degeneration in retinas (n=8) of diabetic C57BL/6 (black) and IL17A−/− (grey) mice normalized to non-diabetic controls. All samples were collected 8 months after diabetic conditions were confirmed. All data is representative of two separate experiments with similar results.