Table 2.
Multivariable regression of the effects of age-at-diagnosis, age-at-testing, sex, tumor location, and treatment on neuropsychological outcomes among survivors of low grade tumors
| Outcome | Independent Variable | Category | Adjusted Mean Difference [β] (95% CI) | P-value |
|---|---|---|---|---|
| Composite Neuropsychological Index | Age-at-Diagnosis | 5-year increase | 3.9 (1 ,6.9) | 0.010 |
| Age-at-Testing | 5-year increase | −1.7 (−3.8 ,0.5) | 0.13 | |
| Sex | Female | Ref | ||
| Male | −1.8 (−5.8 ,2.2) | 0.37 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −2.9 (−7 ,1.3) | 0.18 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −5.8 (−9.8 ,−1.8) | 0.005 | ||
| Estimated IQ | Age-at-Diagnosis | 5-year increase | 4.5 (1.4 ,7.6) | 0.005 |
| Age-at-Testing | 5-year increase | −1.4 (−3.6 ,0.8) | 0.21 | |
| Sex | Female | Ref | ||
| Male | 0.4 (−3.8 ,4.5) | 0.86 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −3.9 (−8.3 ,0.4) | 0.073 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −5.6 (−9.8 ,−1.3) | 0.010 | ||
| Verbal Domain | Age-at-Diagnosis | 5-year increase | 4.3 (1.1 ,7.5) | 0.009 |
| Age-at-Testing | 5-year increase | −1.8 (−4.1 ,0.5) | 0.12 | |
| Sex | Female | Ref | ||
| Male | −0.6 (−4.9 ,3.7) | 0.79 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −4.7 (−9.1 ,−0.2) | 0.040 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −5 (−9.4 ,−0.6) | 0.024 | ||
| Visual-Spatial Domain | Age-at-Diagnosis | 5-year increase | 3.5 (0.3 ,6.7) | 0.034 |
| Age-at-Testing | 5-year increase | −0.5 (−2.8 ,1.8) | 0.66 | |
| Sex | Female | Ref | ||
| Male | 1.6 (−2.8 ,5.9) | 0.48 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −3.1 (−7.6 ,1.5) | 0.18 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −4 (−8.4 ,0.4) | 0.076 | ||
| Memory Domain | Age-at-Diagnosis | 5-year increase | 3.7 (0.4 ,7) | 0.029 |
| Age-at-Testing | 5-year increase | −2 (−4.4 ,0.4) | 0.097 | |
| Sex | Female | Ref | ||
| Male | −3.2 (−7.6 ,1.3) | 0.16 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −2.3 (−6.9 ,2.3) | 0.32 | ||
| Treatment | Surgery-only | Ref | 0.008 | |
| Surgery+RT | −6.1 (−10.6 ,−1.6) | |||
| Attention/Processing Speed Domain | Age-at-Diagnosis | 5-year increase | 2.2 (−1.2 ,5.6) | 0.20 |
| Age-at-Testing | 5-year increase | −0.6 (−3 ,1.8) | 0.64 | |
| Sex | Female | Ref | ||
| Male | 1.2 (−3.4 ,5.7) | 0.62 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | 0 (−4.7 ,4.6) | 0.99 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −5.3 (−9.9 ,−0.7) | 0.025 | ||
| Motor Domain | Age-at-Diagnosis | 5-year increase | 7.1 (1.6 ,12.5) | 0.012 |
| Age-at-Testing | 5-year increase | −3.1 (−7 ,0.8) | 0.12 | |
| Sex | Female | Ref | ||
| Male | −8 (−15.4 ,−0.6) | 0.033 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −3.4 (−11 ,4.2) | 0.38 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −12.8 (−20.3 ,−5.3) | 0.001 | ||
| Executive Domain | Age-at-Diagnosis | 5-year increase | 4.3 (0.7 ,7.9) | 0.020 |
| Age-at-Testing | 5-year increase | −1.1 (−3.7 ,1.5) | 0.40 | |
| Sex | Female | Ref | ||
| Male | −1.3 (−6.2 ,3.6) | 0.60 | ||
| Tumor Location | Infratentorial | Ref | ||
| Supratentorial | −4.8 (−9.9 ,0.3) | 0.063 | ||
| Treatment | Surgery-only | Ref | ||
| Surgery+RT | −3.7 (−8.7 ,1.3) | 0.14 |
Ref=Reference group