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Comparison of ChTS bound to 1 (light green/cyan) and ChTS bound 2 (dark green/magenta) with FdUMP (yellow). A. Comparison of 1 and 2 bound in ChTS active site. ChTS stabilizes 1 with a hydrogen bonding interaction with residue S290 (Black dotted line). ChTS hydrogen bonding interaction between 2 and residue K284 may induce conformational strain (gray dotted line). B. Zoom in view of glutamate moiety of 1 and 2. C. Zoom in view of the pyrrolo[2,3-d]pyrimidine of 1 and 2.
