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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: FEBS Lett. 2019 Jun 18;593(15):2030–2039. doi: 10.1002/1873-3468.13475

Figure 1.

Figure 1

(A) Close-up view of the mortalin nucleotide binding pocket with N6-propargyl ADP bound. Throughout the figure mortalin is shown with each subdomain backbone individually colored (subdomain IA pink; subdomain IB magenta; subdomain IIA white; subdomain IIB cyan), N6-propargyl ADP-Pi (yellow) is shown as sticks, the Mg2+ ion (green) is represented as a sphere and electron density (grey) is displayed as a transparent surface overlay. (B) Close-up of the surface density (orange) view showing possible interaction pockets for N6 modified ADP analogues. (C) Close-up of a transparent surface overlay (pink) showing a pocket unique to mortalin that indicates a possible site for C2 ADP modifications.