Table 2.
Conserved influenza A class II-predicted immunogenic consensus sequences.
| Peptide # | Protein - Starting AA |
Consensus Sequence | EpiMatrix Hits |
EpiBars? (#) | Conservation |
|---|---|---|---|---|---|
| Flu.ICS-2 | M1-58 | GMLGFVFTLTVPSERGLQ | 14 | Yes (2) | 1 |
| Flu.ICS-4 | M1-176 | ENRMVLASTTAKAMEQV | 7 | Yes (1) | 1 |
| Flu.ICS-6 | M1-76 | RRRFVQNALNGNGDPN | 7 | Yes (1) | 1 |
| Flu.ICS-7 | M1-129 | GLIYNRMGAVTTEAA | 6 | Yes (1) | 0.72 |
| Flu.ICS-8 | M1-234 | LENLQAYQKRMGVQMQRF | 6 | Yes (1) | 0.98 |
| Flu.ICS-9 | M1-17 | SGPLKAEIAQRLEDV | 4 | Yes (1) | 0.91 |
| Flu.ICS-10 | M1-170 | NPLIRHENRMVLAST | 3 | No | 0.92 |
| Flu.ICS-11 | M1-135 | MGAVTTEVAFGLVCA | 1 | No | 0.77 |
| Flu.ICS-12 | M1-125 | ASCMGLIYNRMGAVT | 3 | No | 0.98 |
| Flu.ICS-14 | NP-409 | QPAFSVQRNLPFERVTI | 11 | Yes (1) | 1 |
| Flu.ICS-15 | NP-113 | KDEIRRIWRQANNGEDAT | 9 | No | 1 |
| Flu.ICS-16 | NP-51 | DNEGRLIQNSLTIERMVL | 9 | No | 0.72 |
| Flu.ICS-17 | NP-133 | LTHMMIWHSNLNDTTYQR | 8 | Yes (1) | 1 |
| Flu.ICS-18 | NP-216 | RTAYERMCNILKGKF | 6 | Yes (1) | 1 |
| Flu.ICS-19 | NP-261 | RSALILRGSVAHKSCLP | 8 | Yes (1) | 1 |
| Flu.ICS-20 | NP-145 | DATYQRTRALVRSGM | 6 | Yes (1) | 1 |
| Flu.ICS-21 | NP-36 | IGRFYIQMCTELKLNDY | 7 | Yes (1) | 0.98 |
| Flu.ICS-22 | NP-188 | TMVMELIRMIKRGINDRN | 13 | Yes (2) | 0.75 |
| Flu.ICS-23 | NP-381 | LRSMYWAIRTRSGGNTN | 7 | Yes (1) | 1 |
| Flu.ICS-24 | NP-301 | IDPFRLLQNSQVYSLIRP | 14 | Yes (2) | 0.75 |
| Flu.ICS-25 | NP-310 | SQVYSLIRPNENPAHKSQ | 9 | Yes (1) | 0.96 |
| Flu.ICS-26 | NP-204 | RNFWRGENGRKTRSA | 4 | Yes (1) | 0.72 |
| Flu.ICS-28 | NP-75 | RNKYLEEHPSAGKDP | 2 | No | 0.98 |
| Flu.ICS-29 | NP-161 | PRMCSLMQGSTLPRR | 1 | No | 1 |
| Flu.ICS-30 | NP-220 | ERMCNILKGKFQTAA | 1 | No | 1 |
EpiMatrix ‘hit’ defined as a predicted binding Z-score of ≥1.64 to a single class II HLA.
‘EpiBars’ are defined frames for which predicted binding is observed for ≥4 DR alleles.