. Author manuscript; available in PMC: 2020 Aug 1.

Published in final edited form as: J Cardiovasc Transl Res. 2019 Feb 12;12(4):280–289. doi: 10.1007/s12265-019-09866-5

Table 2.

Unadjusted and adjusted logistic regression models for the association of ADRB1 Ser49 homozygous status with recovery of LVEF to ≥ 40%.

Logistic Regression Model	n	OR (for Ser49 homozygotes)	95% CI	^*p
Univariate	98	5.4	1.7 – 17.2	0.004
Adjusted for age, sex, and race	97	6.8	2.0 – 23.4	0.002
Adjusted for sex, SBP, diabetes	89	6.9	1.9 – 25.0	0.003
Adjusted for age, sex, SBP, diabetes, QRS duration,^a and ischemic etiology^a	89	8.4	2.2 – 32.2	0.002
Adjusted for age, sex, race, SBP and diabetes	89	6.9	1.9 – 25.2	0.004
Adjusted for age, race, sex, SBP, diabetes, QRS duration,^a NYHA class,^a and ischemic etiology^a	89	8.2	2.1 – 32.9	0.003
Adjusted for age, race, sex, SBP, diabetes, QRS duration,^a NYHA class,^a and ischemic etiology^b	54	10.9	1.3 – 89.5	0.026

ADRB1 = gene for the beta-1 adrenergic receptor; CI = confidence interval; Gly = glycine; LVEF = left ventricular ejection fraction; NYHA = New York Heart Association; OR = odds ratio; SBP = systolic blood pressure; Ser = serine

^a.

Mean values were used to impute missing data for n = 32 missing QRS duration, n = 40 missing ischemic etiology, and n = 34 missing NYHA functional class.

^b.

This model did not include patients that had non/ischemic etiology imputed. It only included patients in which non/ischemic etiology data was available.

p-value for ADRB1 Ser49 homozygotes versus Gly49 carriers within the specified model. Bolded p-values indicate statistical significance