Table 3.

Full logistic regression model including all clinical covariates and ADRB1 Ser49 homozygous status for the primary outcome of LVEF recovery to ≥ 40%.

Variable	OR	95% CI	*p
ADRB1 Ser49 homozygotes	8.17	2.07 – 32.22	0.003
Age	1.00	0.96 – 1.04	0.991
Female sex	4.07	1.27 – 13.03	0.018
African-American race	1.01	0.29 – 3.51	0.983
Systolic blood pressure	1.03	0.99 – 1.06	0.074
Non-diabetic	0.84	0.28 – 2.51	0.757
aQRS duration	0.98	0.96 – 1.01	0.122
aIschemic etiology	0.93	0.17 – 5.10	0.933
aNYHA functional class	0.69	0.34 – 1.39	0.296

ADRB1 = gene for the beta-1 adrenergic receptor; CI = confidence interval; Gly = glycine; LVEF = left ventricular ejection fraction; OR = odds ratio; SBP = systolic blood pressure; Ser = serine

^a.Mean values were used to impute missing data for n = 32 missing QRS duration, n = 40 missing ischemic etiology, and n = 34 missing NYHA functional class.

^*p-value is for type III analysis of effects; bolded values indicate statistical significance (p < 0.05)