. Author manuscript; available in PMC: 2020 Aug 1.

Published in final edited form as: J Cardiovasc Transl Res. 2019 Feb 12;12(4):280–289. doi: 10.1007/s12265-019-09866-5

Table 4.

Unadjusted and adjusted logistic regression models for the association of ADRB1 Arg389 homozygous status with recovery of LVEF to ≥ 40%.

Logistic Regression Model	n	OR (for Arg389 homozygotes)	95% CI	^p*
Univariate	94	0.49	0.21 - 1.2	0.101
Adjusted for age, sex, and race	93	0.42	0.17 - 1.1	0.063
Adjusted for sex, SBP, diabetes	86	0.49	0.19 - 1.3	0.142
Adjusted for age, sex, SBP, diabetes, QRS duration, and ischemic etiology^a	86	0.55	0.20 - 1.5	0.230
Adjusted for age, sex, race, SBP and diabetes	85	0.48	0.18 - 1.3	0.148
Adjusted for age, race, sex, SBP, diabetes, QRS duration, NYHA class, and ischemic etiology^a	85	0.55	0.19 - 1.5	0.251
Adjusted for age, race, sex, SBP, diabetes, QRS duration,^a NYHA class,^a and ischemic etiology^b	51	0.55	0.13 – 2.2	0.404

ADRB1 = gene for the beta-1 adrenergic receptor; Arg = Arginine; CI = confidence interval; Gly = glycine; LVEF = left ventricular ejection fraction; OR = odds ratio; SBP = systolic blood pressure

^a.

Mean values were used to impute missing data for n = 31 missing QRS duration, n = 39 missing ischemic etiology, and n = 34 missing NYHA functional class.

^b.

This model did not include patients that had non/ischemic etiology imputed. It only included patients in which non/ischemic etiology data was available.

p-value for ADRB1 Arg389Gly genotype within the specified model. Bolded p-values indicate statistical significance