Figure 6.

Imaging chronic pain with ASL. In cLBP patients, rCBF elevations were observed after pain-exacerbating clinical maneuvers (red), but not after the resolution of heat pain (pink) or in healthy volunteers receiving the same stimuli (green) (from Ref. 91). ASL, arterial spin labeling; aINS, anterior insula; BIL, bilateral; cLBP, chronic low-back pain; CTRL, control; HC, healthy controls; L, left side; M1, primary motor cortex; MFG, middle frontal gyrus; MPFC, medial prefrontal cortex; preSMA, presupplementary motor area; R, right side; rCBF, regional cerebral blood flow; S1, primary somatosensory cortex; S2, secondary somatosensory cortex; SMG, supramarginal gyrus; SPL, superior parietal lobule.