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. 2019 Aug 8;12:2473–2485. doi: 10.2147/JPR.S214671

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© 2019 Kuthati et al.

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Continuous intrathecal infusion of melatonin type-2 (MT-2) agonist IIK-7 attenuated the development of nerve-transection-induced neuropathic pain (n=6). Effects of intrathecal infusion of 0.5 μg IIK-7/1 μL/hr, 0.5 μg IIK-7/1 μg +4-Phenyl-2-propionamidotetralin (4-p)/1μl/hr and vehicle/1μL/hr on the mechanical paw withdrawal threshold in ipsilateral paw of partial sciatic nerve-transected rats and sham. PSNT, partial sciatic nerve transection; IIK-7, N-Butanoyl 2-(9-methoxy-6H-iso-indolo[2,1-a]indol-11-yl)-ethan-amine; 4-p, 4-Phenyl-2-propionamidotetralin.