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. 2019 Aug 8;12:2473–2485. doi: 10.2147/JPR.S214671

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© 2019 Kuthati et al.

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Pre-treatment of IIK-7 antagonist 4-p 20 mins prior to IIK-7 administration did not result in significant blockade of IIK-7-induced anti-nociception in nerve-transection-induced neuropathic pain (n=6) . Effects of intrathecal single injection of vehicle 10 μL, 5 μg IIK-7 in 10 μL vehicle, pretreatment with 10 μg 4-p in vehicle 10 μL followed by the single injection of 5 μg IIK-7, on the mechanical paw withdrawal threshold in ipsilateral paw of partial sciatic nerve-transected rats and sham group; n=6 rats per group.

Abbreviations: PSNT, partial sciatic nerve transection; IIK-7, N-Butanoyl 2-(9-methoxy-6H-iso-indolo[2,1-a]indol-11-yl)-ethan-amine; 4-p, 4-Phenyl-2-propionamidotetralin.