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. 2019 Aug 8;12:2473–2485. doi: 10.2147/JPR.S214671

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© 2019 Kuthati et al.

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IIK-7 treatment reduces PSNT-induced iNOS expression in rat spinal cords. (A) On day 6 after drug treatment, spinal cord sections were fixed and single-labeled with iNOS rabbit antibody followed by Alexa flour 594 antibody (red) and the nuclei stained with 4ʹ,6-diamidino-2-phenylindole (blue), then images were captured and merged by fluorescence microscopy. The sections are from (A) vehicle-injected PSNT rats, (B) IIK-7-injected rats. (B) The iNOS activation is quantified by counting the number of cells expressing iNOS relative to the value for the vehicle-injected group. Data are analyzed by Tukey test (*p<0.05). The pictures are representative of those seen in samples from 3 rats.

Abbreviations: IIK-7, N-Butanoyl 2-(9-methoxy-6H-iso-indolo[2,1-a]indol-11-yl)-ethan-amine; DAPI, 4′,6-diamidino-2-phenylindole; iNOS, iNOS Inducible nitric oxide synthase.