Mean change in serum CRP for each disorder before and after the cycle of 6 × 30 min biofeedback sessions (placebo group). The placebo study participants were Caucasian men and women aged between 30 and 86 years. The number of subjects involved was 950, comprising 500 males and 450 females, with an average age of 50 years. In all the subjects, pain was a major feature of their lives. The placebo group had the same procedure as the treated group. The only variant was that the device-patient connection cable was internally silenced, so as to keep all the other variables exactly the same