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. 2019 Aug 13;10(8):611. doi: 10.1038/s41419-019-1860-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a RPMI-8226, MM.1S, and KMS-12BM cells were stimulated with 100 ng/ml TNF for the indicated times in the presence and absence of 20 µM MLN4924. Total cell lysates were analyzed for phosphorylation and degradation of IκBα. b The indicated cell lines were treated overnight with 10 µM of the SMAC mimetic BV6 in the presence and absence of 20 µM MLN4924 and total cell lysates were analyzed for p100 processing. Data shown are representative of at least two independent experiments