Table 1.
MLN4924-induced accumulation of proteins observed by SILAC mass spectrometry
| Gene name of accumulated protein | Log 2 protein expression MLN4924 treated/untreated | ||||
|---|---|---|---|---|---|
| INA6 | KMS11 | L363 | MM1.S | OPM2 | |
| CCND3 | n.d. | 3,62 | 2,25 | 0,60 | n.d. |
| CCND2 | n.d. | 2,57 | 3,80 | 2,47 | 2,79 |
| CDKN2A | 1,87 | 3,58 | 3,84 | n.d. | 3,39 |
| CDT1 | n.d. | 2,26 | 3,03 | 3,22 | 2,82 |
| CTNNB1 | 2,96 | NA | 2,25 | 4,07 | 1,00 |
| ETNK1 | 0,15 | 1,69 | 2,46 | 2,18 | 0,88 |
| FBXO28 | n.d. | n.d. | 1,87 | 2,06 | 1,95 |
| FEM1B | n.d. | n.d. | 3,00 | 1,73 | n.d. |
| FYTTD1 | 1,25 | 1,10 | 0,95 | 2,17 | 1,17 |
| HMOX1 | 2,05 | 3,70 | 0,65 | −0,07 | 2,16 |
| KLHL6 | 0,70 | n.d. | 2,00 | 2,38 | n.d. |
| LRRC58 | 1,48 | 2,86 | 3,06 | 3,38 | 3,35 |
| MCM10 | n.d. | 2,46 | n.d. | 2,91 | n.d. |
| MORF4L1 | 1,45 | 0,87 | 1,79 | 2,15 | 1,50 |
| MORF4L2 | 1,69 | 1,18 | 2,11 | 2,34 | 1,91 |
| MRFAP1 | 2,10 | 2,87 | 2,45 | 0,61 | 2,74 |
| NUSAP1 | 0,09 | 1,02 | 1,36 | 2,38 | 0,82 |
| SHKBP1 | n.d. | 2,13 | 2,00 | n.d. | n.d. |
| SRXN1 | 1,21 | 2,68 | 2,16 | 2,87 | 2,60 |
| TRCP4AP | n.d. | n.d. | 3,56 | 3,24 | n.d. |
| TSPYL1 | 1,20 | n.d. | n.d. | 2,18 | 0,69 |
Factors are listed which were upregulated in at least two MM cell lines with log 2 > 1 and at least once with log 2 > 2. n.d. not detected