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. 2019 Aug 12;9:11613. doi: 10.1038/s41598-019-48006-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Specific stimulation of P2Y11R afforded cardioprotection to AC16 cells against Hypoxia/Reoxygenation injuries. (a) P2Y11R expression (western blot from total proteins) in AC16 cells. (b) P2Y11R expression (densitometric analysis) significantly decreased after H/R (n = 5). Blot images were cropped. For full-length images, see Supplementary Fig. 2. (c) Intracellular cAMP with P2Y11R agonist NF546 (10 µM) ± NF340, n = 3. (d) Viability (MTT) significantly increased with NF546 compared to H/R condition n = 5. (e) ATPi level significantly increased with NF546, NF340 abolished this effect, n = 5. *p < 0.05; **p < 0.01; NS non significant from control condition (CTL/−); ^#p < 0.05 versus NF546 condition.