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. 2019 Aug 12;9:11598. doi: 10.1038/s41598-019-48024-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic gene expression levels of the renin-angiotensin system in healthy and cirrhotic TGR(mREN2)27 rats. (A) Hepatic angiotensinogen mRNA expression in control, BDL (2w, 4w) and CCl4 (10w) intoxicated WT and TGR(mREN2)27 rats. All results were normalized to WT control data, which is shown as a line. Results are expressed as x-fold change. ACE mRNA expression in livers of WT and TGR(mREN2)27 rats. Results of uninjured and injured (BDL 2w, BDL 4w, CCl₄ 10w) rats are expressed as x-fold change to WT control data, which is illustrated as a line. mRNA levels of hepatic ACE2 expressed as x-fold level of transcription normalized to WT controls, shown as a line. (D) Rat renin mRNA expression in livers of WT and TGR(mREN2)27 rats. Results are expressed as x-fold change and normalized to WT controls, represented as a line. (E) Mouse renin mRNA expression in livers of uninjured TGR(mREN2)27 rats and after BDL (2w, 4w) and CCl₄ 10w. Results were normalized to uninjured control TGR(mREN2)27 data and expressed as x-fold change. (F) Mouse renin mRNA expression in hepatocytes of control (sham) and BDL (4w) TGR(mREN2)27 rats. Data are expressed as x-fold change of control TGR(mREN2)27 rats. Error bars are means ± s.e.m. Statistical analyzes; Mann-Whitney t-test. ^*/**/***Indicates p < 0.05/p < 0.005/p < 0.0001 compared to respective WT data. ^#/##/###Indicates p < 0.05/p < 0.005/p < 0.0001 compared to TGR(mREN2)27 control data.