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. 2019 Aug 12;9:11598. doi: 10.1038/s41598-019-48024-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Jak2 upregulation in TGR(mREN2)27 rats. (A) Portal pressure and hepatic-vascular resistance before and after injection of 1 mg/kg AG490. In TGR(mREN2)27 rats, portal pressure was significantly reduced after inhibition of Jak2 by AG490. Unit of portal pressure measurement is mmHg and of hepatic-vascular resistance mmHg*min*100 g/ml. (B) Perfusion pressure in situ in livers of TGR(mREN2)27 rats after precontraction with 5 µM Ang II and after 10⁻⁶ and 10⁻⁵M AG490 in the perfusion buffer. Results are represented as percentage of the basal perfusion pressure. (C) Scratch assay of TGR(mREN2)27 HSC with and without AG490 treatment (5 µM and 25 µM) after 24 h. Migration of TGR(mREN2)27 HSC is represented as percentage of gap. Gap of untreated HSC are normalized to 100%. Error bars are means ± s.e.m. Statistical analyzes; Paired Wilcoxon signed rank test. ^{^/^^}Indicates p < 0.05/p < 0.005 compared to measurement before AG490 treatment. ^#/###Indicates p < 0.05/p < 0.0001 compared to TGR(mREN2)27 control data.