Table 2.
Hemodynamics in healthy and fibrotic TGR(mREN2)27 rats before and after AVE0991 injection.
| Group | Portal pressure (mmHg) | Hepatic-vascular resistance (mmHg*min*100 g/ml) | Splanchnic-vascular resistance (mmHg*min*100 g/ml) | Mean arterial pressure (mmHg) | Systemic-vascular resistance (mmHg*min*100 g/ml) | |
|---|---|---|---|---|---|---|
| TGR(mREN2)27 Ctr. | before AVE0991 | 14.6 ± 0.93 | 3.84 ± 1.05 | 29.45 ± 4.62 | 128.6 ± 4.04 | 29.45 ± 4.62 |
| after AVE0991 | 11.4 ± 0.81** | 2.51 ± 0.85 | 24.43 ± 5.43 | 119.6 ± 6.12 | 24.43 ± 5.43 | |
| TGR(mREN2)27 BDL (4w) | before AVE0991 | 19.75 ± 1.70 | 14.94 ± 1.71 | 15.24 ± 1.65 | 75.5 ± 5.17 | 15.25 ± 1.65 |
| after AVE0991 | 14.25 ± 1.18** | 5.01 ± 1.42* | 27.63 ± 13.35 | 74.75 ± 7.00 | 27.63 ± 13.35 | |
| TGR(mREN2)27 CCl4 (10w) | before AVE0991 | 17.8 ± 0.92 | 9.80 ± 2.43 | 43.40 ± 8.35 | 109.6 ± 5.47 | 43.40 ± 8.35 |
| after AVE0991 | 9.5 ± 1.10*** | 3.53 ± 0.98* | 45.37 ± 8.69 | 126.8 ± 8.99 | 45.37 ± 8.69 | |
*/**/***p < 0.05/p < 0.005/p < 0.0001 vs. before AVE0991.