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. 2019 Aug 12;9:11618. doi: 10.1038/s41598-019-48039-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bland-Altman plots of R5, X5, R_5-19/20, AX, and f_res data obtained with IOS and tremoflo in COPD patients (solid symbols) and healthy control subjects (open symbols). A regression line was fitted to the data and the regression coefficient was calculated. The regression coefficients and associated p-values for the respective variables are; R5: r = −0.57; p = 0.0022; X5: r = −0.96; p = 0.0001; R_5-19/20: r = −0.45; p = 0.0213 f_res: r = −0.72; p = 0.00004; and AX: r = −0.96; p = 0.0001.